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Blade: The Series is a TV series based on the Marvel Comics character Blade, portrayed on the big screen by Wesley Snipes. The series spin-off is likely a result of the success of the Blade Trilogy of films also based on the comic book character. The series premiered on Spike TV on June 28, 2006, with a two-hour pilot written by David Goyer, directed by Geoff Johns, and starring Kirk Jones (Sticky Fingaz) as the half-vampire, half-human Daywalker, Blade.

The series picked up where the last film, Blade: Trinity, left off and added several new characters, including Jill Wagner as Krista Starr, Neil Jackson as Marcus Van Sciver, Jessica Gower as Chase, and Nelson Lee as Shen.

Blade was SpikeTV's first original scripted series and was produced by New Line Cinema. Due to disappointing ratings, the series was not renewed for a second season.

When Krista Starr returns home to Detroit from service in Iraq, she discovers her bother, Zack, has been murdered. Krista tries to hunt down her brother's killer and uncovers a world of vampires she never dreamed existed. She is soon captured by . . .