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In Search Of . . . was a TV series that investigated real-life mysteries. The weekly half-hour documentary series, hosted and narrated by Leonard Nimoy (Star Trek), featured various mysteries by way of interviews, film clips, and some dramatizations. The show aired in syndication and featured one mystery per episode. Mysteries involving various scientific and paranormal phenomena were explored, as well as mysteries surrounding important people and events from history. Some examples of topics include UFOs, Nostradamus, ghosts, Inca treasures, Butch Cassidy, Bigfoot, The Bermuda Triangle, Jesse James, and the lost city of Atlantis.

The series was created after two successful television specials aired: In Search of Ancient Astronauts (1973; based on the book Chariots of the Gods), and In Search of Ancient Mysteries (1975). These documentaries were hosted by Rod Serling (creator of The Twilight Zone). The pilot episode of the series was narrated by Robert Vaughn (The Man from U.N.C.L.E.), who declined to be the regular host.

There is conflicting information regarding the air date of the start of the series. Some sources state that the series began airing in September 1976, while others state that the series started in April 1977. The series ran for six seasons, ending in 1982. A total of 144 episodes were produced and aired. In recent years, repeats of the show have occasionally been aired on various cable channels. In these repeats, a disclaimer is sometimes placed at the beginning of the episode regarding the bias inherent in the show in general (almost every phenomenon is assumed to be true with little evidence, and alternative, non-supernatural viewpoints are nonexistent), and disavowing the veracity of the content within the episode. Leonard Nimoy has parodied himself as the narrator on The Simpsons.

In 2002, a new version of In Search Of . . . aired on The SCI FI Channel. The new series was hosted by Mitch Pileggi (The X-Files) and lasted only eight episodes.

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